By G.O. Evans
By way of providing heritage info at the choice and alertness of biochemical exams in safeguard review stories, this consultant seeks to supply a foundation for making improvements to the information required to intepret data.
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Extra info for Animal clinical chemistry : a primer for toxicologists
Concurrent administration of other drugs can complicate interpretation of effects due to interference. Some of the problems of testing for interferences are shown by studies with several cephalosporins which interfere with creatinine measurements. The measurement of creatinine is important in monitoring renal function following administration of cephalosporin antibiotics, and it is commonly measured with alkaline picrate reagents. , 1991). Durham et al. (1979) showed that by altering the timing of the blood sample in relation to dosing with cefoxitin, the interference could be reduced as the plasma drug levels fell.
Laboratory Animal Science, 26, 959–60. E. E. (1987) Effect of shipping stress on clinicopathologic indicators in F344/N rats. American Journal of Veterinary Research, 48, 306–8. , ROSSINI, M. & REMUZZI, G. (1989) Age-related nephropathy and proteinuria in rats with intact kidneys exposed to diets with different protein content. Laboratory Investigations, 60, 196–204. , KACZMARCZYK, G. W. (1990) Effect of high sodium and high water intake on 24-h-potassium balance in dogs. Zeitschrift Versuchstierkunde, 33, 179–85.
1989). The effects of dehydration on plasma volume and thus biochemical measurements may be obvious with high values for plasma protein and packed cell volume. , 1990). Simple observations of water intake together with urinary output are important when examining this preanalytical variable. Treatment prior to sequential blood sampling in toxicology studies should be similar in respect to food and water intake. The biochemical changes which occur with alterations of nutritionary and fluid balance can be associated with alterations in the absorption or uptake of the test compound, changes in metabolism rates or detoxification mechanisms, modification of renal clearance or changes in the competitive binding of proteins with the test compound.