By Kenneth Bridges, Howard A. Pearson
The 1st finished, but concise, medical advisor to the whole spectrum of anemias Anemias and different pink mobile issues is the 1st source to supply a realistic diagnostic/treatment framework for making a choice on and effectively dealing with acute, congenital, and protracted anemias, and different pink blood phone problems. With its large scope, easy-to-navigate layout, and ready-to-apply diagnostic and remedy techniques, this is often the main obtainable - and crucial - consultant to anemias and comparable illnesses ever released. good points a whole top-to-bottom evaluation of anemias, written with the non-specialist in brain Logical bankruptcy association in line with the scientific positive aspects that steered the preliminary stumble upon among health care professional and sufferer Discussions of anemias on the topic of physiological stipulations resembling anemia in age and being pregnant, or because of endocrine and metabolic conditions--categories which are regularly encountered in scientific perform yet hardly ever addressed in conventional hematology texts A unified sufferer administration procedure in every one constantly formatted bankruptcy Key Diagnostic positive aspects and Key administration concerns tables inside every one bankruptcy functional insights that assist you overview pathologic fabric to figure out the presence and severity of the illness assurance of therapy modalities on the leading edge of medical perform, together with chemotherapy, monoclonal antibodies, and stem and hematopoietic stem mobilephone transplantation
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Extra info for Anemias and Other Red Cell Disorders
FIGURE 2–1 The idea is plausible, in particular given the slow accumulation of DNA damage over the years due to background radiation, environmental mutagens, and the like. The pluripotent hematopoietic stem cell divides rarely, reproducing itself while generating a daughter cell that moves into the pathway of hematopoietic cell production (Figure 2-1). Could some of these self-replications fail to produce a new stem cell, leading to a decline over time in their number? Stem cells comprise a tiny fraction of the hematopoietic cells in the bone marrow.
BONE MARROW Bone marrow examination has a special place in the anemia work-up since it is the organ of blood production. A key issue to be addressed by the physician is whether a bone marrow examination is needed to assess a particular case of anemia. The CHAPTER 1 PRINCIPLES OF ANEMIA EVALUATION 17 procedure changes the nature of the anemia evaluation because it requires the technical expertise of a hematologist or pathologist. The reticulocyte count often provides the basis for estimating the possible utility of a bone marrow examination.
Patients on total parenteral nutritional support can develop signiﬁcant copper deﬁciency with associated anemia and brittle hair. Clues to the etiology of an anemia can surface with careful skin examination. Anemia commonly produces pallor. However, the ﬁnding often is masked in patients with prominent skin pigmentation. Careful examination of unpigmented regions of epithelium such as mucous membranes and the nail beds can unveil otherwise cryptic pallor. Jaundice can reﬂect rapid erythrocyte turnover due to a hemolytic anemia.