By Wojciech Gorczyca
This vast reference protecting neoplastic hematopathology comprises over 500 color illustrations depicting hematopoietic tumors related to lymph nodes, spleen, bone marrow, and often affected extranodal organs, with detailed emphasis at the differential analysis. It discusses simple medical, prognostic, morphologic and phenotypic information, with quite a few tables summarizing the phenotypic profiles of the most typical hematologic tumors. an incredible function of this publication is an method of hematologic tumors in accordance with the WHO type, with suitable examples and emphasis at the most valuable morphologic and immunophenotypic positive aspects utilized in diagnosis.It should be a useful reference for all working towards hematologists, oncologists and pathologists.
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Extra info for An Atlas of Differential Diagnosis in Neoplastic Hematopathology
TALL/LBL more often shows dimmer expression of CD45, lack of CD2 and CD3 (surface), dual positive or dual negative CD4/CD8 expression, lack of TCR, and expression of CD10 and CD117 when compared to mature tumors20,22. 19 Flow cytometry immunophenotyping—CD4:CD8 ratio. Apart from evaluation of pan-T antigens, the CD4:CD8 ratio is a very useful parameter in flow cytometric analysis of hematolymphoid lesions (A–D). Predominance of either CD4+ or CD8+ cells, dual expression of CD4/CD8 or lack of both CD4/CD8, although not completely diagnostic, may indicate malignancy (including both mature/post-thymic and precursor lesions).
8 presents an immunophenotypic profile of major categories of peripheral (mature/post-thymic) T-cell disorders. 17 Flow cytometry immunophenotyping—criteria to identify abnormal T-cell population (see text for details). Upper panels represent a benign lymph node. Note moderate expression of all four pan-T antigens (arrow). Lower panels represent an example of T-cell lymphoma with aberrant expression of CD2 (brighter than normal T-cells marked with *), loss of CD5 and CD7, and increased forward scatter (arrow).
Note increase in forward scatter and loss of CD5 and CD7 in T-cell lymphoma (residual benign T-cells are marked with *). 6 shows the frequency of loss or diminished expression of pan-T antigens in different types of peripheral T-cell lymphoproliferations. Normal expression of all four pan-T antigens does not exclude T-cell lymphoma. Typical (moderate-bright) expression of all four antigens is present in 32% of peripheral (mature) T-cell lymphomas, most commonly in T-prolymphocytic leukemia (T-PLL; 57%), followed by AILD (25%), Sezary’s syndrome (12%), anaplastic large cell lymphoma (11%), T-LGL (8%), and peripheral T-cell lymphoma, unspecified (7%).