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By James L McGaugh and Sara B. Kiesler (Eds.)

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Chart for meeting on aging, Santa Barbara, Calif. Lapin, B. , Krilova, R. , Cherkovich, G. , and Asanov, N. S. (1979) Observations from Sukhumi. Pp. 14-37 in D. M. , Aging in Nonhuman Primates. New York: Van Nostrand Reinhold Co. Laughlin, W. S. (1972) Ecology and population structure in the Arctic. In G. A. Harrison and A. J. , The Structure of Human Populations. Oxford: Clarendon Press. Leakey, M. D. (1979) Footprints in the ashes of time. National Geographic 155:446-457. 2. , and Lenski, J. (1974) Human Societies: An Introduction to Macrosociology.

Noting that the neurotransmitter serotonin is synthesized with tryptophan as a precursor, 3. LIFE-SPAN EXTENSION 47 these experiments suggest that a decrease in the rate of the neuroendocrine program of development could perhaps result in life-span extension (Timiras 1978). D. Denckla and co-workers have perhaps found the most impressive means to rejuvenate and extend health in old animals (Denckla 1975). It is well known that specific metabolic rate gradually decreases with age in mammals. However, when specific metabolic rate is measured in animals of different ages with body temperature maintained at a constant level, a very dramatic drop with age becomes apparent.

However, these animals have been found to have diurnal and/or seasonal variations in body temperature and consequently in specific metabolic rate. For example, the Peromyscus deer mouse would be predicted to have a mean specific metabolic rate according to body size about 35% higher than is actually found, but these animals frequently enter a torpor condition nightly, which substantially reduces their daily metabolic rate. Hummingbirds and bats have a very high specific metabolic rate when flying, but their body temperatures decrease about 13-17°C and 3-6°C, respectively, when they are resting or sleeping.

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