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By Keith Green (auth.), Keith Green, Henry F. Edelhauser, Robert B. Hackett, David S. Hull, David E. Potter, Ramesh C. Tripathi (eds.)

This quantity represents the complaints of the 5th Congress of the foreign Society of Ocular Toxicology (ISOT), which used to be held on the Grove Park hotel and lodge in Asheville, North Carolina, October 13-17, 1996. we're overjoyed to offer this quantity to the ophthalmic group, particularly people with an important curiosity in ocular toxicol­ ogy. The 5th Congress used to be built round topics on the subject of ocular drug metabolism, the ocular pathophysiological results of nitric oxide, executive matters with regards to using substitute tools for toxicity trying out, and a workshop that encompassed comparisons of either in vitro as opposed to in vivo types in addition to various animal versions. the end result of this congress, embodied during this quantity, is a contribution to the methodologies at present hired or less than improvement and to varied drug or actual results on assorted ocular tissues. whereas the focal point of this complaints is on ocular results of gear or different fabrics, some of the contributions take care of issues that experience a much wider curiosity. The workshop in regards to the use of other version platforms and the alternative of the simplest animal version for drug trying out covers quite a lot of pursuits that ex­ has a tendency some distance past particular ocular results. this can be very true within the zone of other tools and within the number of the simplest animal version for exam of alternative illness entities.

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Angiogenic activity of the corneal epithelium. Exp Eye Res 1985; 41 :721-732. 107. Eliason JA. Leukocytes and experimental corneal vascularization. Invest Ophthalmol Vis Sci 1978; 17: 1087-1 09S. 108. Sholley MM, Gimbrone MA, Cotran RS. The effects of leukocyte depletion on corneal vascularization. Lab Invest 1978; 38:32-40. 109. Camp RDR, Cunningham FM, Fincham NJ, Greaves MW, Black AK, Mallet AI, Woollard PM. Psoriatic skin lesions contain a novel lipid neutrophil chemokinetic compound which is distinct from known chemoattractant compounds.

109. Camp RDR, Cunningham FM, Fincham NJ, Greaves MW, Black AK, Mallet AI, Woollard PM. Psoriatic skin lesions contain a novel lipid neutrophil chemokinetic compound which is distinct from known chemoattractant compounds. Br J Phannacol 1988; 94: I 043-1 OSO. 110. Camp RDR, Mallet AI, Woollard PM, Brain SD, Black AK, Greaves MW. The identification of hydroxy fatty acids in psoriatic skin. Prostaglandins 1993; 26:431-448. III. Van Wauwe J, Coene M-C, Van Nyen G, Cools W, Goossen J, Lejeune L, Lauwers W, Janssen PAJ.

Two reasons may have prevented the advancement of the idea of the importance of protein thiolation in cataracts. First, there was no reliable method to differentiate and quantify the protein-thiol mixed disulfides, thus the reported PSSG value varied considerably. Second, interest in the protein-thiol mixed disulfide in cataracts was diminished after negative results in an osmotic induced cataract model were reported suggesting that the protein thiolation process did not appear to play an essential role in cataractogenesis.

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