Download ADAMTS13: Biology and Disease by George M. Rodgers PDF

By George M. Rodgers

This finished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and scientific learn. The 9 authoritative chapters commence with a old point of view by way of exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising study issues for ADAMTS13 are coated, together with its strength function in angiogenesis and different features of cellphone biology. extra subject matters comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and bought ADAMTS13 deficiency. A bankruptcy on comparable thrombotic microangiopathic (TMA) issues examines the diversities among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy experiences the initial info on rising elements of ADAMTS13, akin to the prestige of recombinant ADAMTS13 items and their power utility.

Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion medication physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.

Show description

Read Online or Download ADAMTS13: Biology and Disease PDF

Best hematology books

Advances in Immunology

This quantity contains the cumulative topic index for volumes 37 to sixty five of the "Advances in Immunology" sequence.

Haematology Nursing

Haematology Nursing is a accomplished guide, with a nursing concentration, at the care and administration of sufferers with haematological problems. Divided into 4 sections, the 1st offers an advent to haematology, taking a look at haemopoiesis, immunology and genetics. part covers non-malignant haematology, together with anaemia, haemoglobinopathies and haemochromatosis.

Practical Flow Cytometry in Haematology Diagnosis

Functional movement Cytometry in Haematology analysis Dr Mike Leach, Dr Mark Drummond and Dr Allyson Doig division of Haematology, Gartnavel normal clinic, Glasgow, united kingdom Haematology division, Beatson West of Scotland melanoma Centre, Glasgow, united kingdom division of Haematology, Gartnavel health facility, Glasgow, united kingdom The exact prognosis of haematologic malignancies is a posh and hard activity.

Hematopoietic Stem Cell Protocols

Updating and development upon prior variants, Hematopoietic Stem phone Protocols, 3rd version offers up to date protocols from top stem phone researchers. This in-depth quantity offers a transparent view of the panorama of assays on hand to the stem mobile researcher operating within the growing to be hematopoietic stem phone (HSC) box.

Additional resources for ADAMTS13: Biology and Disease

Sample text

Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov AA, KuscheGullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ, Fessler JH. Papilin in development; a pericellular protein with a homology to the ADAMTS metalloproteinases. Development. 2000;127(24):5475–85. 64. Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, Wang Y, Ogata M, Nishimatsu H, Moriyama N, Oh-hashi Y, Morita H, Ishikawa T, Nagai R, Yazaki Y, Matsushima K. ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.

FEBS Lett. 1999;445(2-3):223–5. 4. Hurskainen TL, Hirohata S, Seldin MF, Apte SS. ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family. J Biol Chem. 1999;274(36):25555–63. 5. Abbaszade I, Liu RQ, Yang F, Rosenfeld SA, Ross OH, Link JR, Ellis DM, Tortorella MD, Pratta MA, Hollis JM, Wynn R, Duke JL, George HJ, Hillman Jr MC, Murphy K, Wiswall BH, Copeland RA, Decicco CP, Bruckner R, Nagase H, Itoh Y, Newton RC, Magolda RL, Trzaskos JM, Burn TC, et al.

29. Kozma K, Keusch JJ, Hegemann B, Luther KB, Klein D, Hess D, Haltiwanger RS, Hofsteenge J. Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. J Biol Chem. 2006;281(48): 36742–51. 30. Ricketts LM, Dlugosz M, Luther KB, Haltiwanger RS, Majerus EM. O-fucosylation is required for ADAMTS13 secretion. J Biol Chem. 2007;282(23):17014–23. 31. Wang LW, Dlugosz M, Somerville RP, Raed M, Haltiwanger RS, Apte SS.

Download PDF sample

Rated 4.03 of 5 – based on 21 votes