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By Shayne Cox Gad; Christopher P Chengelis

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And Gad, S. C. (1995). Information sources: Building and maintaining data files. In Safety Assessment for Pharmaceuticals (S. C. ). Van Nostrand Reinhold, New York. Lu, F. C. (1985). Basic Toxicology, pp. 68-95. Hemisphere, New York. Page, N. P. (1986). International harmonization of toxicity testing. In Safety Evaluation of Drugs and Chemicals (W. E. ), pp. 455-467. Hemisphere, New York. Russell, W. M. , and Burch, R. L. (1959). The Principles of Humane Experimental Technique. Methuen, London.

Not validated in the sense used in this chapter. NA, not applicable. Acute Toxicology Testing 52 mance against various small groups of compounds for which the dermal irritation potential is known. Evaluation by multiple laboratories of a wider range of structures will be essential before any of these systems can be generally utilized. PERCUTANEOUS ABSORPTION Closely related to all aspects of evaluating dermal irritation and corrosion must be an understanding of what factors influence the absorption of materials through the skin, and also the bases of variation of such absorption due to species, sex, age, technique, etc.

And Gad, S. C. (1995). Information sources: Building and maintaining data files. In Safety Assessment for Pharmaceuticals (S. C. ). Van Nostrand Reinhold, New York. Lu, F. C. (1985). Basic Toxicology, pp. 68-95. Hemisphere, New York. Page, N. P. (1986). International harmonization of toxicity testing. In Safety Evaluation of Drugs and Chemicals (W. E. ), pp. 455-467. Hemisphere, New York. Russell, W. M. , and Burch, R. L. (1959). The Principles of Humane Experimental Technique. Methuen, London.

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