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By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Board on Chemical Sciences and Technology, Committee on the Design and Evaluation of Safer Chemical Substitutions: A Framework to Inform Governme

Traditionally, laws governing chemical use have usually curious about wide-spread chemical compounds and acute human wellbeing and fitness results of publicity to them, in addition to their power to reason melanoma and different antagonistic healthiness results. As clinical wisdom has improved there was an elevated expertise of the mechanisms wherein chemical compounds could exert destructive results on human well-being, in addition to their results on other  Read more...

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This can be done by incorporating different alternatives over part or all of a product’s life cycle and estimating the broader environmental impacts associated with these flows. Use life cycle assessment methods to assess potential social and socioeconomic impacts of each alternative over its life cycle. Inputs: List of alternatives from Step 7 and result of Life Cycle Thinking (Step 8). Outputs: Assessment of the relative life cycle impacts of alternatives. Frameworks: BizNGO and IC2 Broader environmental impacts of alternatives can be informed by comparing the life cycles of the alternatives and their implications for how alternatives differ in resource consumption and materials emitted.

A more complete discussion of goals, principles, and decision rules and their impacts on alternatives assessments can be found in Chapters 4 and 9. 27 Step 2b: Problem Formulation—Gather Information on the Chemical of Concern and Determine Assessment Methods All the frameworks include the collection of preliminary information about the original chemical to facilitate the assessment. This activity also has been included in the committee’s framework. Information to be collected includes the following:  The identity of the chemical of concern (and any relevant structurally-related chemicals) must be clearly established because the scope of the assessment and the range of potential alternatives can be affected by this determination.

Frameworks: BizNGO, CA SCP, DfE, German Guide, IC2, Lowell, REACH, TURI, UNEP, and UCLA MCDA Every framework explicitly or implicitly integrates the findings from human health and ecological assessments to provide decision makers with the potential impacts of the alternatives. The committee’s framework also includes a step to integrate human health and ecological information from Step 6. Step 7 acts as a decision point, meaning that if there are no safer alternatives for further assessment, additional research can be initiated to develop new alternatives or improve existing ones.

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